Studies on a Mechanism by Which Cytosolic Phospholipase A2 Regulates the Expression and Function of Type IIA Secretory Phospholipase A2

Phospholipase A and Function of Type IIA Secretory Regulates the Expression 2 Phospholipase A Studies on a Mechanism by Which Cytosolic Ichiro Kudo

Involvement of cytosolic phospholipase A2 and secretory phospholipase A2 in arachidonic acid release from human neutrophils.

The purpose of this study was to define the role of secretory phospholipase A2 (sPLA2), calcium-independent PLA2, and cytosolic PLA2 (cPLA2) in arachidonic acid (AA) release from fMLP-stimulated human neutrophils. While fMLP induced the release of extracellular sPLA2 activity and AA, 70% of sPLA2 activity remained associated with the cell. Treatment with the cell-impermeable sPLA2 inhibitors DT...

Labour is associated with increased expression of type-IIA secretory phospholipase A2 but not type-IV cytosolic phospholipase A2 in human myometrium.

Human labour is associated with increased prostaglandin synthesis within the uterus. The aim of this study was to examine the expression of the type-IV cytosolic phospholipase A2 (cPLA2-IV) and the type IIA secretory phospholipase A2 (sPLA2-IIA) in myometrium in association with labour onset at term and preterm deliveries. These enzymes are important for the release of the prostaglandin precurs...

effect of polyunsaturated fatty acids on secretory phospholipase a2 type iia in ectopic endometrial cells

background: endometriosis is a common chronic inflammation which leads to infertility and chronic pelvic pain in affected women. secretory phospholipase a2 type iia (spla2iia) is an acute phase reactant that is markedly increased in inflammatory disorders. objective: to assess the effects of ω-3 and ω-6 polyunsaturated fatty acids (pufas) administration in endometrial cells culture on spla2iia ...

Secretory phospholipase A2 type IIA: a regulator of immune function in atherosclerosis?

Soluble phospholipase A2 type IIA (sPLA2-IIA) is an acutephase reactant that is markedly increased in inflammatory disorders including cardiovascular disease. Inflammatory cytokines such as interleukins IL-6 and IL-1b, interferon (IFN)-g, and tumour necrosis factor (TNF)-a increase its expression in vascular smooth muscle cells and hepatocytes, two cell types largely responsible for its elevati...